ea0065op3.2 | Metabolism and Obesity | SFEBES2019
Arvaniti Anastasia
, Harris Shelley
, Nikolaou Nikolaos
, Cox Roger
, Odermatt Alex Alex
, Tomlinson Jeremy
, Gathercole Laura
Disruption of the gut-liver axis contributes to metabolic syndrome and the progression of non-alcoholic fatty liver disease (NAFLD). Bile acids (BAs) are potent antimicrobials that support gastrointestinal health and dysregulation of BA homeostasis in NAFLD is thought to contribute to gut dysbiosis. Furthermore, an increase in hydrophobic (cytotoxic) BA species may directly affect gut health. We have previously shown that bile acid synthesis enzyme, 5β-reductase (AKR1D1),...